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1

Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (−)-[18F]Flubatine in humans

Patt, Marianne, Becker, Georg A., Grossmann, Udo, Habermann, Bernd, Schildan, Andreas, Wilke, Stephan, Deuther-Conrad, Winnie, Graef, Susanne, Fischer, Steffen, Smits, René, Hoepping, Alexander, Wagen

Journal:

Nuclear Medicine and Biology

Année:

2014

Langue:

english

Fichier:

PDF, 418 KB

english, 2014

2

Radiosynthesis and first evaluation in mice of [18F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors

Rötering, Sven, Scheunemann, Matthias, Fischer, Steffen, Hiller, Achim, Peters, Dan, Deuther-Conrad, Winnie, Brust, Peter

Journal:

Bioorganic & Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 406 KB

english, 2013

3

Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [18F]NS14490

Sven Rötering,Winnie Deuther-Conrad,Paul Cumming,Cornelius K Donat…

Journal:

EJNMMI Research

Année:

2014

Langue:

english

Fichier:

PDF, 794 KB

english, 2014

4

Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition and H3R Antagonism with Sigma 1R Agonism Profile

Bautista-Aguilera, Oscar M., Budni, Josiane, Mina, Francielle, Medeiros, Eduarda Behenck, Deuther-Conrad, Winnie, Entrena, Jose-Manuel, Moraleda, Ignacio, Iriepa, Isabel, López-Muñoz, Francisco, Marco

Journal:

Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 978 KB

english, 2018

5

Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A 2B receptor

Lindemann, Marcel, Hinz, Sonja, Deuther-Conrad, Winnie, Namasivayam, Vigneshwaran, Dukic-Stefanovic, Sladjana, Teodoro, Rodrigo, Toussaint, Magali, Kranz, Mathias, Juhl, Cathleen, Steinbach, Jörg, Bru

Journal:

Bioorganic & Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 1.85 MB

english, 2018

6

Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18

Wenzel, Barbara, Liu, Jianrong, Dukic-Stefanovic, Sladjana, Deuther-Conrad, Winnie, Teodoro, Rodrigo, Ludwig, Friedrich-Alexander, Chezal, Jean-Michel, Moreau, Emmanuel, Brust, Peter, Maisonial-Besset

Journal:

Bioorganic Chemistry

Année:

2019

Fichier:

PDF, 1.70 MB

2019

7

Norchloro-fluoro-homoepibatidine (III): Specificity to Neuronal Nicotinic Acetylcholine Receptor Subtypes in vitro.

Winnie Deuther-Conrad, Joerg Thomas Patt, Dominik Feuerbach, Florian Wegner, Peter Brust, Joerg Steinbach

Journal:

Année:

2005

Fichier:

PDF, 13 KB

2005

8

A 18F-Labeled Fluorobutyl-Substituted Spirocyclic Piperidine Derivative as a Selective Radioligand for PET Imaging of Sigma1 Receptors

Dr. Aurélie Maisonial, Dr. Eva Große Maestrup, Dr. Steffen Fischer, Dr. Achim Hiller, Dr. Matthias Scheunemann, Dr. Christian Wiese, Dr. Dirk Schepmann, Prof. Jörg Steinbach, Dr. Winnie Deuther-Conrad

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 491 KB

english, 2011

9

Preparation and biological evaluation of 99mTcN-4-(cyclohexylpiperazin-1-yl)-dithioformate as a potential sigma receptor imaging agent

Jie Lu, Dejing Kong, Hongmei Jia, Winnie Deuther-Conrad, Peter Brust, Xuebin Wang

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2007

Langue:

english

Fichier:

PDF, 127 KB

english, 2007

10

Radiosynthesis of novel 18F-labelled derivatives of indiplon as potential GABAA receptor imaging tracers for PET

Steffen Fischer, Achim Hiller, Matthias Scheunemann, Winnie Deuther-Conrad, Alexander Hoepping, Michael Diekers, Florian Wegner, Peter Brust, Jörg Steinbach

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2008

Langue:

english

Fichier:

PDF, 246 KB

english, 2008

11

Synthesis and biological evaluation of a radioiodinated spiropiperidine ligand as a potential σ1 receptor imaging agent

Rui-Qin Chen, Yan Li, Qiu-Yan Zhang, Hong-Mei Jia, Winnie Deuther-Conrad, Dirk Schepmann, Jörg Steinbach, Peter Brust, Bernhard Wünsch, Bo-Li Liu

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2010

Langue:

english

Fichier:

PDF, 192 KB

english, 2010

12

In vitro binding profile and radiosynthesis of a novel 18F-labeled azaspirovesamicol analog as potential ligand for imaging of the vesicular acetylcholine transporter

Barbara Wenzel, Achim Hiller, Steffen Fischer, Dietlind Sorger, Winnie Deuther-Conrad, Matthias Scheunemann, Peter Brust, Osama Sabri, Jörg Steinbach

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2011

Langue:

english

Fichier:

PDF, 273 KB

english, 2011

13

Synthesis of fluorine substituted pyrazolopyrimidines as potential leads for the development of PET-imaging agents for the GABAA receptors

Alexander Hoepping, Michael Diekers, Winnie Deuther-Conrad, Matthias Scheunemann, Steffen Fischer, Achim Hiller, Florian Wegner, Jörg Steinbach, Peter Brust

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 251 KB

english, 2008

14

Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter

R. Ben-Daniel, W. Deuther-Conrad, M. Scheunemann, J. Steinbach, P. Brust, E. Mishani

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 210 KB

english, 2008

15

3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT)

Mitja Kovac, Sylvie Mavel, Winnie Deuther-Conrad, Nathalie Méheux, Jana Glöckner, Barbara Wenzel, Marko Anderluh, Peter Brust, Denis Guilloteau, Patrick Emond

Journal:

Bioorganic & Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 720 KB

english, 2010

16

Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging

Zi-Jing Li, Hui-Ying Ren, Meng-Chao Cui, Winnie Deuther-Conrad, Rui-Kun Tang, Jörg Steinbach, Peter Brust, Bo-Li Liu, Hong-Mei Jia

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 427 KB

english, 2011

17

New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET

Johnny Vercouillie, Winnie Deuther-Conrad, Matthias Scheunemann, Patrick Emond, Steffen Fischer, Uta Funke, Jörg Steinbach, Denis Guilloteau, Peter Brust

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 148 KB

english, 2007

18

3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: Chemical synthesis, evaluation in vitro and radiofluorination

Uta Funke, Steffen Fischer, Achim Hiller, Matthias Scheunemann, Winnie Deuther-Conrad, Peter Brust, Jörg Steinbach

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 219 KB

english, 2008

19

β-Amyloid peptide potentiates inflammatory responses induced by lipopolysaccharide, interferon -γ and ‘advanced glycation endproducts’ in a murine microglia cell line

Jovana Gasic-Milenkovic, Sladjana Dukic-Stefanovic, Winnie Deuther-Conrad, Ullrich Gärtner, Gerald Münch

Journal:

European Journal of Neuroscience

Année:

2003

Langue:

english

Fichier:

PDF, 352 KB

english, 2003

20

Signal transduction pathways in mouse microglia N-11 cells activated by advanced glycation endproducts (AGEs)

Sladjana Dukic-Stefanovic, Jovana Gasic-Milenkovic, Winnie Deuther-Conrad, Gerald Münch

Journal:

Journal of Neurochemistry

Année:

2003

Langue:

english

Fichier:

PDF, 347 KB

english, 2003

21

Differences in the modulating potential of advanced glycation end product (AGE) peptides versus AGE proteins

Deuther-Conrad, Winnie, Franke, Sybille, Sommer, Manfred, Henle, Thomas, Stein, Gunter

Journal:

Kidney International

Année:

2001

Fichier:

PDF, 625 KB

2001

22

Autoradiography of 2-[18F]F-A-85380 on nicotinic acetylcholine receptors in the porcine brain in vitro

Winnie Deuther-Conrad, Andrea Wevers, Georg Becker, Andreas Schildan, Marianne Patt, Osama Sabri, Jörg Steinbach, Peter Brust

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 437 KB

english, 2006

23

In vivo measurement of nicotinic acetylcholine receptors with [18F]norchloro-fluoro-homoepibatidine

Peter Brust, Jörg Thomas Patt, Winnie Deuther-Conrad, Georg Becker, Marianne Patt, Andreas Schildan, Dietlind Sorger, Kai Kendziorra, Philipp Meyer, Jörg Steinbach, Osama Sabri

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 581 KB

english, 2008

24

Molecular imaging of α7 nicotinic acetylcholine receptors: design and evaluation of the potent radioligand [18F]NS10743

Winnie Deuther-Conrad, Steffen Fischer, Achim Hiller, Elsebet Østergaard Nielsen, Daniel Brunicardi Timmermann, Jörg Steinbach, Osama Sabri, Dan Peters, Peter Brust

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Année:

2009

Langue:

english

Fichier:

PDF, 259 KB

english, 2009

25

Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1selective radioligand [18F]fluspidine

Steffen Fischer, Christian Wiese, Eva Große Maestrup, Achim Hiller, Winnie Deuther-Conrad, Matthias Scheunemann, Dirk Schepmann, Jörg Steinbach, Bernhard Wünsch, Peter Brust

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Année:

2011

Langue:

english

Fichier:

PDF, 351 KB

english, 2011

26

Assessment of α7 nicotinic acetylcholine receptor availability in juvenile pig brain with [18F]NS10743

Winnie Deuther-Conrad, Steffen Fischer, Achim Hiller, Georg Becker, Paul Cumming, Guoming Xiong, Uta Funke, Osama Sabri, Dan Peters, Peter Brust

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Année:

2011

Langue:

english

Fichier:

PDF, 528 KB

english, 2011

27

Novel99mTc labeled σ receptor ligand as a potential tumor imaging agent

Caiyun Fan, Hongmei Jia, Winnie Deuther-Conrad, Peter Brust, Jörg Steinbach, Boli Liu

Journal:

Science China Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 2.36 MB

english, 2006

28

Synthesis andin vitroevaluation of new diphenyl ether derivatives as serotonin transporter ligands

YunHang Guo, XiangJi Chen, HongMei Jia, Winnie Deuther-Conrad, Peter Brust, Jörg Steinbach, Johnny Vercouillie, BoLi Liu

Journal:

Science China Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 159 KB

english, 2008

29

Alterations of cholinergic receptors and the vesicular acetylcholine transporter after lateral fluid percussion injury in newborn piglets

C. K. Donat, B. Walter, W. Deuther-Conrad, B. Wenzel, K. Nieber, R. Bauer, P. Brust

Journal:

Neuropathology and Applied Neurobiology

Année:

2010

Langue:

english

Fichier:

PDF, 453 KB

english, 2010

30

Protein „AGEing”– cytotoxicity of a glycated protein increases with its degree of AGE-modification

Gasic-Milenkovic, J., Loske, C., Deuther-Conrad, W., M&#x000FC, nch, G.

Journal:

Zeitschrift für Gerontologie und Geriatrie

Année:

2001

Fichier:

PDF, 110 KB

2001

31

Synthesis, radiofluorination and pharmacological evaluation of a fluoromethyl spirocyclic PET tracer for central σ1 receptors and comparison with fluoroalkyl homologs

Aurélie Maisonial, Eva Große Maestrup, Christian Wiese, Achim Hiller, Dirk Schepmann, Steffen Fischer, Winnie Deuther-Conrad, Jörg Steinbach, Peter Brust, Bernhard Wünsch

Journal:

Bioorganic & Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 899 KB

english, 2012

32

Postnatal development and kinetics of [3H]gaboxadol binding in rat brain: In vitro homogenate binding and quantitative autoradiography

Anne Friemel, Bjarke Ebert, Pete H. Hutson, Peter Brust, Karen Nieber, Winnie Deuther-Conrad

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2007

33

Time-dependent alterations of cholinergic markers after experimental traumatic brain injury

Cornelius K. Donat, Martin U. Schuhmann, Cornelia Voigt, Karen Nieber, Winnie Deuther-Conrad, Peter Brust

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 1.29 MB

english, 2008

34

GABAA receptor pharmacology of fluorinated derivatives of the novel sedative-hypnotic pyrazolopyrimidine indiplon

Florian Wegner, Winnie Deuther-Conrad, Matthias Scheunemann, Peter Brust, Steffen Fischer, Achim Hiller, Michael Diekers, Karl Strecker, Kai Wohlfarth, Clemens Allgaier, Jörg Steinbach, Alexander Hoep

Journal:

European Journal of Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 856 KB

english, 2008

35

Norchloro-fluoro-homoepibatidine: specificity to neuronal nicotinic acetylcholine receptor subtypes in vitro

Winnie Deuther-Conrad, Jörg Thomas Patt, Dominik Feuerbach, Florian Wegner, Peter Brust, Jörg Steinbach

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 237 KB

english, 2004

36

Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer’s disease

Amanda Wong, Hans-Joachim Lüth, Winnie Deuther-Conrad, Sladjana Dukic-Stefanovic, Jovana Gasic-Milenkovic, Thomas Arendt, Gerald Münch

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 1.40 MB

english, 2001

37

Effects of lateral fluid percussion injury on cholinergic markers in the newborn piglet brain

Cornelius K. Donat, Bernd Walter, Tanja Kayser, Winnie Deuther-Conrad, Reinhard Schliebs, Karen Nieber, Reinhard Bauer, Wolfgang Härtig, Peter Brust

Journal:

International Journal of Developmental Neuroscience

Année:

2010

Langue:

english

Fichier:

PDF, 1.25 MB

english, 2010

38

[11C]SMe-ADAM, an imaging agent for the brain serotonin transporter: synthesis, pharmacological characterization and microPET studies in rats

Jörg Zessin, Winnie Deuther-Conrad, Marion Kretzschmar, Frank Wüst, Beate Pawelke, Peter Brust, Jörg Steinbach, Ralf Bergmann

Journal:

Nuclear Medicine and Biology

Année:

2006

Langue:

english

Fichier:

PDF, 499 KB

english, 2006

39

Radiosynthesis and biological evaluation of an 18F-labeled derivative of the novel pyrazolopyrimidine sedative–hypnotic agent indiplon

Alexander Hoepping, Matthias Scheunemann, Steffen Fischer, Winnie Deuther-Conrad, Achim Hiller, Florian Wegner, Michael Diekers, Jörg Steinbach, Peter Brust

Journal:

Nuclear Medicine and Biology

Année:

2007

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2007

40

Immunochemical detection of imidazolone in uremia and rheumatoid arthritis

S Franke, T Niwa, W Deuther-Conrad, M Sommer, G Hein, G Stein

Journal:

Clinica Chimica Acta

Année:

2000

Langue:

english

Fichier:

PDF, 918 KB

english, 2000

41

Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism

Winnie Deuther-Conrad, Claudia Loske, Reinhard Schinzel, Ralf Dringen, Peter Riederer, Gerald Münch

Journal:

Neuroscience Letters

Année:

2001

Langue:

english

Fichier:

PDF, 117 KB

english, 2001

42

Synthesis and biological evaluation of 18F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging

Xia Wang, Yan Li, Winnie Deuther-Conrad, Fang Xie, Xin Chen, Meng-Chao Cui, Xiao-Jun Zhang, Jin-Ming Zhang, Jörg Steinbach, Peter Brust, Bo-Li Liu, Hong-Mei Jia

Journal:

Bioorganic & Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 758 KB

english, 2013

43

Norchloro-fluoro-homoepibatidine (NCFHEB) — A promising radioligand for neuroimaging nicotinic acetylcholine receptors with PET

W. Deuther-Conrad, J.T. Patt, P.R. Lockman, D.D. Allen, M. Patt, A. Schildan, V. Ganapathy, J. Steinbach, O. Sabri, P. Brust

Journal:

European Neuropsychopharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 364 KB

english, 2008

44

[3H]Gaboxadol binding sites characterised by in vitro autoradiography on pig brain and homogenate studies in rat

Anne Friemel, P. Hutson, B. Ebert, P. Brust, W. Deuther-Conrad

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 56 KB

english, 2006

45

[18F]NS10743: Characterisation of a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) radioligand in pig brain by PET

Winnie Deuther-Conrad, Steffen Fischer, Achim Hiller, Uta Funke, Elsebet Østergaard Nielsen, Daniel Brunicardi Timmermann, Jörg Steinbach, Dan Peters, Peter Brust

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 52 KB

english, 2010

46

Evaluation of Spirocyclic 3-(3-Fluoropropyl)-2-benzofurans as σ 1 Receptor Ligands for Neuroimaging with Positron Emission Tomography

Große Maestrup, Eva, Fischer, Steffen, Wiese, Christian, Schepmann, Dirk, Hiller, Achim, Deuther-Conrad, Winnie, Steinbach, Jörg, Wünsch, Bernhard, Brust, Peter

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.95 MB

english, 2009

47

A 3D-QSAR model for cannabinoid receptor (CB2) ligands derived from aligned pharmacophors

Robert Günther, Winnie Deuther-Conrad, Rareś Moldovan…

Journal:

Journal of Cheminformatics

Année:

2013

Langue:

english

Fichier:

PDF, 106 KB

english, 2013

48

Cannabinoid receptor type 2 (CB2)-selectiveN-aryl-oxadiazolyl-propionamides: synthesis, radiolabelling, molecular modelling and biological evaluation

Thomas Rühl, Winnie Deuther-Conrad…

Journal:

Organic and Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2012

49

Synthesis and biological evaluation of both enantiomers of [18F]flubatine, promising radiotracers with fast kinetics for the imaging of α4β2-nicotinic acetylcholine receptors

Smits, René, Fischer, Steffen, Hiller, Achim, Deuther-Conrad, Winnie, Wenzel, Barbara, Patt, Marianne, Cumming, Paul, Steinbach, Jörg, Sabri, Osama, Brust, Peter, Hoepping, Alexander

Journal:

Bioorganic & Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 932 KB

english, 2014

50

Hydroxyalkylation with Cyclic Sulfates: Synthesis of Carbazole Derived CB 2 Ligands with Increased Polarity

Lueg, Corinna, Galla, Fabian, Frehland, Bastian, Schepmann, Dirk, Daniliuc, Constantin G., Deuther-Conrad, Winnie, Brust, Peter, Wünsch, Bernhard

Journal:

Archiv der Pharmazie

Année:

2014

Langue:

english

Fichier:

PDF, 255 KB

english, 2014